BfB / ehem. Photomed Archiv

Vitamin D reguliert die Regeneration  und verhindert die Überproduktion von Zellen. Bei einer täglichen Menge an Vitamin D von 1.000 IU (International Units) reduziert sich nach jüngsten Studien das Risiko für diese Krebsarten um mindestens 50%.

Höhere (kumulative) UV-Exposition scheint ein protektiver Faktor gegen das Wachstum von Carcinomen innerer Organe zu sein.

Hier einige exemplarische Studien zu Vitamin D und seinen Einfluss auf Prävention und Therapie einzelner Krebsarten.

Eine Checkliste der allgemeinen Gesundheitswirkungen von Sonne und Vitamin D finden Sie hier. - (als Gesamtdokument zum Download - PDF148 k)

Mehrere Krebsarten

Francis P Boscoe, Maria J Schymura, Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002, BMC Cancer 2006, 6:264, PDF

Bauchspeicheldrüsenkrebs

Halcyon G. Skinner, Dominique S. Michaud, Edward Giovannucci, Walter C. Willett, Graham A. Colditz and Charles S. Fuchs, Vitamin D Intake and the Risk for Pancreatic Cancer in Two Cohort Studies, Cancer Epidemiology Biomarkers & Prevention Vol. 15, 1688-1695, September 2006

Brustkrebs

Julia A. Knight et al., Vitamin D and Reduced Risk of Breast Cancer: A Population-Based Case-Control Study, Cancer Epidemiology Biomarkers & Prevention 16, 422-429, March 1, 2007

Grant W.B., An ecologic study of dietary and solar ultraviolet-B links to breast carcinoma mortality rates, Cancer. 2002 Jan 1;94(1):272-81.

William B. Grant, Breast cancer ? risk and risk reduction factors, SUNARC 2004

Martin Lipkin, Harold L. Newmark, Vitamin D, Calcium and Prevention of Breast Cancer: A Review, Journal of the American College of Nutrition, Vol. 18, No. 5, 392S?397S (1999)

Yan Cui and Thomas E. Rohan, Vitamin D, Calcium, and Breast Cancer Risk: A Review, Cancer Epidemiology Biomarkers & Prevention Vol. 15, 1427-1437, August 2006

Eierstock-Krebs

Garland C, et al. Role of ultraviolet irradiance and vitamin D in prevention of ovarian cancer. Am J Prev Med 31(6), 2006.

Darmkrebs

Edward Giovannucci , Yan Liu , Eric B. Rimm , Bruce W. Hollis , Charles S. Fuchs ,
Meir J. Stampfer , Walter C. Willett, Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men, Journal of the National Cancer Institute, Vol. 98, No. 7, April 5, 2006

Giovannucci E., The epidemiology of vitamin D and colorectal cancer: recent findings, Curr Opin Gastroenterol. 2006 Jan;22(1):24-9

William B. Grant, Risk and risk reduction factors for colon and rectal cancer, SUNARC 2004

Grant WB, Garland CF. A critical review of studies on vitamin D in relation to colorectal cancer. Nutrition and Cancer, 2004;48:115-23.

Cedric F. Garland and Frank C. Garland, Do sunlight and vitamin D reduce the likelihood of colon cancer?   Int. J. Epidemiol. 2005 10.1093

CS Spina, V Tangpricha, M Uskokovic, L Adorinic, H Maehr, and MF Holick, Vitamin D and cancer. Anticancer Res, July 1, 2006; 26(4A): 2515-24.

Hautkrebs

Berwick M, Armstrong BK, Ben-Porat L, Fine J, Kricker A, Eberle C, et al. Sun exposure and mortality from melanoma. J Natl Cancer Inst 2005 ; 97 : 195 ? 9.

Veierod MB, et al.; A prospective study of pigmentation, sun exposure, and risk of cutaneous malignant melanoma in women, J Natl Cancer Inst. 2003 Oct 15;95(20):1530-8 - und die nachfolgende lebhafte Diskussion in JNCI

Lungenkrebs

Zhou W, Suk R, Liu G, Park S, Neuberg DS, Wain JC, et al. Vitamin D is associated with overall survival in early stage non-small cell lung cancer patients. Cancer Epidemiol Biomarkers Prev 2005 ; 14 : 2303 ? 9

Liu PT, et al.,Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response, Science. 2006 Mar 24;311(5768):1770-3.

Lymphom

Hughes AM,et al., Sun exposure may protect against non-Hodgkin lymphoma: a case-control study, Int J Cancer. 2004 Dec 10;112(5):865-71

Adami J, Gridley G, Nyren O, Dosemeci M,Linet M, Glimelius B, Ekbom A, Zahm SH, Sunlight and non-Hodgkin's lymphoma: a population-based cohort study in Sweden, Int J Cancer. 1999 Mar 1;80(5):641-5.

Hartge P,Lim U, Freedman DM, Colt JS, Cerhan JR, Cozen W, Severson RK, Davis S., Ultraviolet radiation, dietary vitamin D, and risk of non-Hodgkin lymphoma (United States), Cancer Causes Control. 2006 Oct;17(8):1045-52

Prostata-Krebs

Schwartz, GG; Vitamin D and the epidemiology of prostate cancer, Semin Dial. 2005 Jul-Aug;18(4):276-89

Vieth R, et al., Rise in Prostate-Specific Antigen in Men with Untreated Low-Grade Prostate Cancer Is Slower During Spring-Summer, Am J Ther. 2006 September/October;13(5):394-399

Grant WB, A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality, Eur Urol. 2004 Mar;45(3):271-9

Esther M. John, Gary G. Schwartz, Jocelyn Koo, David Van Den Berg and Sue A. Ingles, Sun Exposure, Vitamin D Receptor Gene Polymorphisms, and Risk of Advanced Prostate Cancer, Cancer Research 65, 5470-5479, June 15, 2005

Tai C. Chen and Michael F. Holick, Vitamin D and prostate cancer prevention and treatment, TRENDS in Endocrinology and Metabolism Vol.14 No.9 November 2003

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Stand: Oktober 2006